1,2-Dioleoyl-3-dimethylammonium-propane (Synonyms: 18:1 DAP) |
| Catalog No.GC18352 |
1,2-Dioleoyl-3-dimethylammonium-propane is a cationic lipid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 127512-29-2
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-3-dimethylammonium-propane (DODAP) is a cationic lipid. It has been used as a component in liposomes that can be used to encapsulate siRNA, immunostimulatory oligodeoxynucleotides, antisense oligonucleotides, or chemotherapeutic agents for in vitro and in vivo delivery. [1][2][3]
Reference:
[1]. Dabbas, S., Kaushik, R.R., Dandamudi, S., et al. Importance of the liposomal cationic lipid content and type in tumor vascular targeting: Physicochemical characterization and in vitro studies using human primary and transformed endothelial cells. Endothelium 15(4), 189-201 (2008).
[2]. Hamzah, J., Altin, J.G., Herringson, T., et al. Targeted liposomal delivery of TLR9 ligands activates spontaneous antitumor immunity in an autochthonous cancer model. J. Immunol. 183(2), 1091-1098 (2009).
[3]. Mendonça, L.S., Firmino, F., Moreira, J.N., et al. Transferrin receptor-targeted liposomes encapsulating anti-BCR-ABL siRNA or asODN for chronic myeloid leukemia treatment. Bioconjug. Chem. 21(1), 157-168 (2010).
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