1,2-Dioleoyl-3(R)-trimethylammoniumpropane (chloride) |
| Catalog No.GC90744 |
A cationic lipid
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 328250-28-8
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-3(R)-trimetlammoniumpropane (R-DOTAP) is a cationic lipid and the more immunologically active isomer of DOTAP .1,2 Lipoplexes containing R-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells.1 Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in R-DOTAP-containing liposomes induces IFN-γ production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) and decreases tumor size in a murine cervical cancer model.2 Subcutaneous immunization with recombinant influenza B hemagglutinin using R-DOTAP as an adjuvant increases IL-2 and IFN-γ production in CD4+ T cells isolated from mouse draining lymph nodes and spleen.3
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