1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt |
| Catalog No.GC68485 |
1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt (18:1 PA; DOPA) is an anionic lipid that can be used to prepare liposomes, micelles, and artificial membranes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 108392-02-5
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt (18:1 PA; DOPA) is an anionic lipid that can be used to prepare liposomes, micelles, and artificial membranes[1]. 1,2-Dioleoyl-sn-glycero-3-phosphate is a phospholipid containing the long-chain fatty acid oleic acid inserted at the sn-1 and sn-2 positions[2]. 1,2-Dioleoyl-sn-glycero-3-phosphate is one of the major phosphatidic acid (PA) species in most tissues and cells[3]. 1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt can be used to prepare Zol-Ca composite nanoparticle formulations to improve the delivery and enhance the distribution of Zol in mouse tumor models[4]. Calcium phosphate (CaP)-coated DOPA liposomes have good biomembrane staining ability[5].
References:
[1] Siepi E. Mechanism of amphoteric liposomes & application for siRNA delivery[D]. Halle (Saale), Martin-Luther-Universität Halle-Wittenberg, Diss., 2010, 2010.
[2] Rouet‐Mayer M A, Valentova O, Simond‐Côte E, et al. Critical analysis of phospholipid hydrolyzing activities in ripening tomato fruits. Study by spectrofluorimetry and high‐performance liquid chromatography[J]. Lipids, 1995, 30(8): 739-746.
[3] Hoshino F, Sakane F. Polyunsaturated fatty acid-containing phosphatidic acids selectively interact with L-lactate dehydrogenase A and induce its secondary structural change and inactivation[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2020, 1865(10): 158768.
[4] Li X, Naguib Y W, Valdes S, et al. Reverse Microemulsion-Based Synthesis of (Bis) phosphonate–Metal Materials with Controllable Physical Properties: An Example Using Zoledronic Acid–Calcium Complexes[J]. ACS applied materials & interfaces, 2017, 9(16): 14478-14489.
[5] Berti I R, Dell’Arciprete M L, Dittler M L, et al. Delivery of fluorophores by calcium phosphate-coated nanoliposomes and interaction with Staphylococcus aureus biofilms[J]. Colloids and Surfaces B: Biointerfaces, 2016, 142: 214-222.
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