1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (sodium salt) (Synonyms: LPA 20:0,PA(20:0/0:0),1-Arachidoyl LPA,1-Arachidoyl Lysophosphatidic Acid,1-Eicosanoyl-2-hydroxy-sn-glycero-3-phosphate,20:0 LPA)

1-Arachidoyl-2-hydroxy-sn-glycero-3-PA (1-arachidoyl LPA) is an agonist of lysophosphatidic acid receptor 1 (LPA₁) and a glycerophospholipid containing arachidic acid at the sn-1 position.^[1] It induces calcium mobilization in primary human lung fibroblasts (EC₅₀ = 3.6 µM), which endogenously express LPA₁ but not LPA₂-LPA₆. 1-Arachidoyl LPA (2.5 µM) also binds to the ligand-binding domain of peroxisome proliferator-activated receptor γ (PPARγ) in a cell-free assay.^[2] It has been found in human urine.^[3]

References:
[1].Sattikar, A., Dowling, M.R., and Rosethorne, E.M.Endogenous lysophosphatidic acid (LPA1) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblastsBr. J. Pharmacol.174(3)(2017).
[2].Tsukahara, T., Tsukahara, R., Yasuda, S., et al.Different residues mediate recognition of 1-O-oleyl-lysophosphatidic acid and rosiglitazone in the ligand binding domain of peroxisome proliferator-activated receptor γJ. Biol. Chem.281(6)3398-3407(2006).
[3].Lim, S., Byeon, S.K., Lee, J.Y., et al.Computational approach to structural identification of phospholipids using raw mass spectra from nanoflow liquid chromatography-electrospray ionization-tandem mass spectrometryJ. Mass. Spectrom.47(8)1004-1014(2012).