15-keto Prostaglandin E2-d9 (Synonyms: 15-keto PGE2-d9, 15-oxo PGE2-d9) |
| Catalog No.GC46450 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2738376-66-2
Sample solution is provided at 25 µL, 10mM.
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15-keto Prostaglandin E2-d9 (15-keto PGE2-d9) is intended for use as an internal standard for the quantification of 15-keto PGE2 by GC- or LC-MS. 15-keto PGE2 is a metabolite of PGE2 formed by 15-hydroxy PGDH.1,2 In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).3
1.Hamberg, M., and Samuelsson, B.On the metabolism of prostaglandins E1 and E2 in manJ. Biol. Chem.246(22)6713-6721(1971) 2.Mak, O.T., Liu, Y., and Tai, H.H.Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidneyBiochim. Biophys. Acta1035(2)190-196(1990) 3.Nishigaki, N., Negishi, M., and Ichikawa, A.Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonistMol. Pharmacol.50(4)1031-1037(1996)
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