3-deoxy Glucosone (Synonyms: 2-keto-3-Deoxyglucose) |
| Catalog No.GC40744 |
3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 4084-27-9
Sample solution is provided at 25 µL, 10mM.
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3-deoxy Glucosone is a highly reactive 2-oxoaldehyde intermediate of the Maillard reaction produced during oxidative stress in response to excess sugar consumption and in association with diabetes.[1] [2]I[3] t is a precursor for the formation of advanced glycation endproducts and because it readily reacts with protein amino groups is also used for crosslinking studies.[4] 3-deoxy Glucosone can be used as a reference for the analysis and detection of glucose degradation products and glycating agents.
Reference:
[1]. Yamada, H., Miyata, S., Igaki, N., et al. Increase in 3-deoxyglucosone levels in diabetic rat plasma. Specific in vivo determination of intermediate in advanced Maillard reaction. The Journal of Biological Chemisty 269(32), 20275-20280 (1994).
[2]. Kusunoki, H., Miyata, S., Ohara, T., et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. Diabetes Care 26(6), 1889-1894 (2003).
[3]. Niwa, T., and Tsukushi, S. 3-Deoxyglucosone and AGEs in uremic complications: Inactivation of glutathione peroxidase by 3-deoxyglucosone. Kidney Int.Suppl. 78, S37-S41 (2001).
[4]. Thornalley, P.J., Langborg, A., and Minhas, H.S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochemistry Journal 344(Pt 1), 109-116 (1999).
| Cas No. | 4084-27-9 | SDF | |
| Synonyms | 2-keto-3-Deoxyglucose | ||
| Chemical Name | 3-deoxy-D-erythro-hexos-2-ulose | ||
| Canonical SMILES | OC[C@@H](O)[C@@H](O)CC(C=O)=O | ||
| Formula | C6H10O5 | M.Wt | 162.1 |
| Solubility | 1mg/mL in ethanol, 20mg/mL in DMSO, or in DMF | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 6.169 mL | 30.8452 mL | 61.6903 mL |
| 5 mM | 1.2338 mL | 6.169 mL | 12.3381 mL |
| 10 mM | 0.6169 mL | 3.0845 mL | 6.169 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)
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