3-hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium salt) (Synonyms: DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3) |
| Catalog No.GC46599 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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3-hydroxy-3-methylglutaryl-Coenzyme A-d3 is intended for use as an internal standard for the quantification of 3-hydroxy-3-methylglutaryl-coenzyme A by GC- or LC-MS. 3-hydroxy-3-methylglutaryl-Coenzyme A (HMG-CoA) is an intermediate in several metabolic pathways.1,2,3,4 Conversion of HMG-CoA to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway.3,2 Alternatively, HMG-CoA can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase.4,1 HMG-CoA is also an intermediate in the degradation of leucine.4
1.Laffel, L.Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetesDiabetes Metab. Res. Rev.15(6)412-426(1999) 2.Espenshade, P.J., and Hughes, A.L.Regulation of sterol synthesis in eukaryotesAnnu. Rev. Genet.41401-427(2007) 3.Honda, A., Salen, G., Nguyen, L.B., et al.Regulation of early cholesterol biosynthesis in rat liver: Effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activitiesHepatology27(1)154-159(1998) 4.Berg, J.M., Tymoczko, J.L., and Stryer, L.Section 25.5 NAD+, FAD, and coenzyme A are formed from ATPBiochemistry5th Edition(2002)
| Cas No. | N/A | SDF | |
| Synonyms | DL-3-hydroxy-3-methylglutaryl-CoA-d3, HMG-CoA-d3, Hydroxymethylglutaryl-CoA-d3 | ||
| Canonical SMILES | O[C@@H]1[C@H](OP([O-])([O-])=O)[C@@H](COP(OP(OCC(C)(C)[C@](O)([H])C(NCCC(NCCSC(CC(O)(C([2H])([2H])[2H])CC(O)=O)=O)=O)=O)([O-])=O)([O-])=O)O[C@H]1N2C3=C(C(N)=NC=N3)N=C2.[NH4+].[NH4+].[NH4+].[NH4+] | ||
| Formula | C27H37D3N7O20P3S.4NH4 | M.Wt | 982.8 |
| Solubility | Water: 50 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.0175 mL | 5.0875 mL | 10.175 mL |
| 5 mM | 0.2035 mL | 1.0175 mL | 2.035 mL |
| 10 mM | 0.1018 mL | 0.5088 mL | 1.0175 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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