γ-Acetylenic GABA hydrochloride |
| Catalog No.GC70650 |
γ-Acetylenic GABA (GAG) hydrochloride is an irreversible inhibitor of GABA-transaminase.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 103451-26-9
Sample solution is provided at 25 µL, 10mM.
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γ-Acetylenic GABA hydrochloride (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2].
References:
[1]. Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9.
[2]. Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36.
[3]. Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203.
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