Ac-IETD-AFC (trifluoroacetate salt) (Synonyms: N-Acetyl-Ile-Glu-Thr-Asp-7-amino-4-Trifluoromethylcoumarin) |
| Catalog No.GC49725 |
A fluorogenic substrate for caspase-8
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Ac-IETD-AFC is a fluorogenic substrate that can be cleaved by caspase-8 and related enzymes that recognize the amino acid sequence IETD, including caspase-3 processing enzyme, caspase-10, and granzyme B.1 Caspase activity can be quantified by fluorescent detection of free AFC (also known as 7-amino-4-trifluoromethylcoumarin), which is excited at 400 nm and emits at 505 nm.
1.Reszka, P., Schulz, R., Methling, K., et al.Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substratesChemMedChem5(1)103-117(2010)
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