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ADAMTS-5-IN-2

Catalog No.GC70743

ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM.

Products are for research use only. Not for human use. We do not sell to patients.

ADAMTS-5-IN-2 Chemical Structure

Cas No.: 294648-66-1

Size Price Stock Qty
10mM (in 1mL DMSO)
$221.00
In stock
1 mg
$162.00
In stock
5 mg
$324.00
In stock
10 mg
$486.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
ADAMTS-5-IN-2 (compound 25) is a potent ADAMTS-5 inhibitor with an IC50 value of 0.71 µM. ADAMTS-5-IN-2 has the potential for the research of modifying osteoarthritis.

References:
[1]. Bompiani KM, et al. High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes. ACS Comb Sci. 2016 Aug 8;18(8):461-74.
[2]. Matthew G. Bursavich; et al. 5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2). Bioorganic & Medicinal Chemistry Letters. 2007, 17(20), 5630-5633.

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