Akuammine (Synonyms: (-)-Akuammine, Vincamajoridine) |
| Catalog No.GC49639 |
An indole alkaloid with analgesic activity
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Cas No.: 3512-87-6
Sample solution is provided at 25 µL, 10mM.
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Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity.1 It selectively binds to the μ- and κ-opioid receptors over the δ-opioid receptor (Kis = 0.3, 1.68, and 10.4 µM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human μ- or κ-opioid receptors (IC50s = 2.6 and 0.073 µM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
1.Creed, S.M., Gutridge, A.M., Argade, M.D., et al.Isolation and pharmacological characterization of six opioidergic Picralima nitida alkaloidsJ. Nat. Prod.84(1)71-80(2021)
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