1,2-Dioleoyl-3(S)-trimethylammoniumpropane (chloride) |
| رقم الكتالوجGC90745 |
دهون موجبة الشحنة (كاتيونية)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 428506-51-8
Sample solution is provided at 25 µL, 10mM.
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1,2-Dioleoyl-3(S)-trimetlammoniumpropane (S-DOTAP) is a cationic lipid and the less immunologically active isomer of DOTAP .1,2 Lipoplexes containing S-DOTAP and encapsulating siRNA targeting the gene encoding aromatase, CYP19A1, decrease aromatase activity in MCF-7 breast cancer cells.1 Vaccination with a peptide epitope from human papillomavirus (HPV) 16 protein E7 in S-DOTAP-containing liposomes decrease tumor size but do not induce IFN-γ production by CD8+ T cells and tumor-infiltrating lymphocytes (TILs) in a murine cervical cancer model.2
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