12-O-Methylcarnosic acid (Synonyms: Carnosic acid 12-methyl ether, 12-Methoxycarnosic Acid) |
رقم الكتالوجGC64008 |
حمض 12-O-Methylcarnosic (12-Methoxycarnosic acid) ، حمض ديتيربين carnosic المعزول من مستخلص الأسيتون من Salvia microphylla ، هو مكون نشط لتثبيط 5α-reductase مع قيمة IC50 61.7 ميكرومتر
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Cas No.: 62201-71-2
Sample solution is provided at 25 µL, 10mM.
12-O-Methylcarnosic acid (12-Methoxycarnosic acid), a diterpene carnosic acid isolated from the acetone extract of Salvia microphylla, is an active constituent of 5α-reductase inhibition with an IC50 value of 61.7 μM. 12-O-Methylcarnosic acid inhibits proliferation in LNCaP cells. 12-O-Methylcarnosic acid has antioxidant, anti-cancer and antimicrobial activity[1][2].
12-O-Methylcarnosic acid (12-Methoxycarnosic acid; 5 μM) inhibits androgen-dependent proliferation of LNCaP cells as 66.7%[1]. 12-O-Methylcarnosic acid shows antimicrobial activity against S. aureus at 78 μg/mL[2].
[1]. Kazuya Murata, et al. Promotion of Hair Growth by Rosmarinus Officinalis Leaf Extract. Phytother Res. 2013 Feb;27(2):212-7.
[2]. Zeynep Aydogmu?, et al. Constituents of Salvia Microphylla. Nat Prod Res. 2006 Jul 10;20(8):775-81.
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