15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester (Synonyms: 15-deoxy-δ12,14-PGJ2-2-glyceryl ester) |
| رقم الكتالوجGC91402 |
يتم تشكيل استر 15-ديوكسي -δ12،14-بروستاجلاندين ج2-2-غليسيريل (15-deoxy-δ12,14-PGJ2-2-glyceryl ester) من PGD2 عن طريق إزالة جزيئات الماء اثنتان.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester (15-deoxy-δ12,14-PGJ2-2-glyceryl ester) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-δ12,14-PGJ2-2-glyceryl ester is more potent than PGD2, δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1 PG glycerol esters are generated by the action of cyclooxygenase-2 on the endocannabinoid 2-arachidonyl glycerol.3 The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. While the stability and metabolism of these PG products has been investigated,4 little is known about their intrinsic biological activity.
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