الصفحة الرئيسية>>(±)9(10)-EpOME-d4

(±)9(10)-EpOME-d4 (Synonyms: (±)9,10EODEd4, Leukotoxind4)

رقم الكتالوجGC46267

A neuropeptide with diverse biological activities

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(±)9(10)-EpOME-d4 التركيب الكيميائي

Cas No.: 1215168-54-9

الحجم السعر المخزون الكميّة
25 μg
155٫00
متوفر
50 μg
294٫00
متوفر
100 μg
555٫00
متوفر
250 μg
1234٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (±)9(10)-EpOME-d4

(±)9,10-EpOME-d4 contains four deuterium atoms at the 9, 10, 12, and 13 positions. It is intended for use as an internal standard for the quantification of latanoprost by GC- or LC-mass spectrometry (MS). (±)9(10)-EpOME is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst.1 It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome.2 Mitochondrial dysfunction is the main feature of (±)9(10)-EpOME cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.3,4

1.Hayakawa, M., Sugiyama, S., Takamura, T., et al.Neutrophils biosynthesize leukotoxin, 9,10-epoxy-12-octadecenoateBiochem. Biophys. Res. Commun.137(1)424-430(1986) 2.Ozawa, T., Hayakawa, M., Takamura, T., et al.Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxiaBiochem. Biophys. Res. Commun.134(3)1071-1078(1986) 3.Kosaka, K., Suzuki, K., Hayakawa, M., et al.Leukotoxin, a linoleate epoxide: Its implication in the late death of patients with extensive burnsMol. Cell. Biochem.139(2)141-148(1994) 4.Moran, J.H., Weise, R., Schnellmann, R.G., et al.Cytotoxicity of linoleic acid diols to renal proximal tubular cellsToxicol. Appl. Pharmacol.146(1)53-59(1997)

Chemical Properties of (±)9(10)-EpOME-d4

Cas No. 1215168-54-9 SDF
المرادفات (±)9,10EODEd4, Leukotoxind4
Canonical SMILES CCCCC/C([2H])=C([2H])\C[C@](O1)([2H])[C@]1([2H])CCCCCCCC(O)=O
Formula C18H28D4O3 M.Wt 300.5
الذوبان DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (±)9(10)-EpOME-d4

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.3278 mL 16.6389 mL 33.2779 mL
5 mM 0.6656 mL 3.3278 mL 6.6556 mL
10 mM 0.3328 mL 1.6639 mL 3.3278 mL
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In vivo Formulation Calculator (Clear solution) of (±)9(10)-EpOME-d4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 34 reference(s) in Google Scholar.)

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