2'-Deoxy-3'-O-(N'-methylanthraniloyl)guanosine-5'-O-triphosphate (sodium salt) |
| رقم الكتالوجGC90852 |
مشتق دي جي تي بي مُضِئ
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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2'-Deoxy-3'-O-(N'-metlanthraniloyl)guanosine-5'-O-triphosphate (2’-deoxy-3’-MANT-GTP) is a fluorescent derivative of dGTP .1,2,3 It selectively inhibits recombinant mammalian adenylyl cyclase 1 (AC1), AC2, AC5, and AC6 (Kis = 260, 1,200, 420, and 470 nM, respectively), bovine lung soluble guanylyl cyclase (sGC; Ki = 220 nM), and B. anthracis edema factor AC toxin (Ki = 630 nM) over rat testis soluble AC (sAC) and B. pertussis AC toxin (Kis = 43 and 14 µM, respectively).1 2’-deoxy-3’-MANT-GTP has been used to study the activity of various GTPases, including elongation factor Tu (EF-Tu) and H-Ras p21.2,3
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