2-Fluoroadenine (Synonyms: F-Ade, NSC 27364) |
| رقم الكتالوجGC46545 |
2-الفلوروادينين عبارة عن قواعد بيورين سامة2-فلوروادينين له سمية في الخلايا السرطانية غير المتكاثرة والمتكاثرة2-فلوروادينين يمكن استخدامه للبحث عن السرطان
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Cas No.: 700-49-2
Sample solution is provided at 25 µL, 10mM.
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2-Fluoroadenine is a heterocyclic building block that has been used in the synthesis of heat shock protein 90 (Hsp90) inhibitors that have anticancer activity in vitro.1 It is also cytotoxic to CEM human leukemia cells with an IC50 value of 0.15 µM.2
1.Llauger, L., He, H., Kim, J., et al.Evaluation of 8-arylsulfanyl, 8-arylsulfoxyl, and 8-arylsulfonyl adenine derivatives as inhibitors of the heat shock protein 90J. Med. Chem.48(8)2892-2905(2005) 2.Parker, W.B., Allan, P.W., Shaddix, S.C., et al.Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cellsBiochem. Pharmacol.55(10)1673-1681(1998)
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