3,3’-Sulfinyldipropanoic Acid (Synonyms: 3,3-Sulfinyldipropionic Acid, 3,3'-Thiodipropionic Acid) |
| رقم الكتالوجGC52015 |
An APE1/Ref-1 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 8/8/3680
Sample solution is provided at 25 µL, 10mM.
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3,3’-Sulfinyldipropanoic acid is an inhibitor of apurinic-apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1; IC50 = 40 µM), an enzyme involved in base excision repair.1 It is also a building block in the synthesis of the protein cross-linking probe disuccinimidyl sulfoxide .2
1.Zawahir, Z., Dayam, R., Deng, J., et al.Pharmacophore guided discovery of small-molecule human apurinic/apyrimidinic endonuclease 1 inhibitorsJ. Med. Chem.52(1)20-32(2009) 2.Kao, A., Chiu, C.-l., Vellucci, D., et al.Development of a novel cross-linking strategy for fast and accurate identification of cross-linked peptides of protein complexesMol. Cell. Proteomics10(1)M110.002212(2011)
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