3-Hydroxy Midostaurin (Synonyms: CGP52421) |
| رقم الكتالوجGC39689 |
3-Hydroxy Midostaurin (CGP 52421) ، مستقلب PKC412 ، يمنع بشكل فعال التيروزين كيناز 3 (FLT3) الشبيه بـ FMS مع IC50s بحوالي 132 نانومتر و 9.8 ميكرومتر في وسط الثقافة والبلازما ، على التوالي3-Hydroxy Midostaurin أقل انتقائية ولكنه أكثر سمية للخلايا من PKC412
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Cas No.: 179237-49-1
Sample solution is provided at 25 µL, 10mM.
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3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
[1]. Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108(10):3477-83.
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