5-O-Methylembelin |
| رقم الكتالوجGC72679 |
5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression.
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Cas No.: 56005-10-8
Sample solution is provided at 25 µL, 10mM.
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5-O-Methylembelin (compound 3; 20 μM; 24 h) downregulates PCSK9 (IC50 value of 4.9 μM), IDLR, and SREBP2 mRNA expression significantly[1].
References:
[1]. Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305.
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