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6H05 (TFA)

رقم الكتالوجGC60533

6H05 TFA هو مثبط انتقائي ، ومثبط خيفي للطفرات الورمية K-Ras (G12C)

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6H05 (TFA) التركيب الكيميائي

Cas No.: 2061344-88-3

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
167٫00
متوفر
2mg
86٫00
متوفر
5mg
129٫00
متوفر
10mg
227٫00
متوفر

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مراجعات العميل

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Sample solution is provided at 25 µL, 10mM.

Description of 6H05 (TFA)

6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.

Chemical Properties of 6H05 (TFA)

Cas No. 2061344-88-3 SDF
Canonical SMILES O=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F
Formula C22H31ClF3N3O4S3 M.Wt 590.14
الذوبان DMSO: ≥ 51 mg/mL (86.42 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 6H05 (TFA)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.6945 mL 8.4726 mL 16.9451 mL
5 mM 0.3389 mL 1.6945 mL 3.389 mL
10 mM 0.1695 mL 0.8473 mL 1.6945 mL
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In vivo Formulation Calculator (Clear solution) of 6H05 (TFA)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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