A011 |
| رقم الكتالوجGC91113 |
مثبط لإنزيم ATM كيناز
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
A011 is an inhibitor of ataxia-telangiectasia mutated (ATM) kinase (IC50 = 1 nM).1 It is selective for ATM over a panel of 408 additional kinases at 10 µM. A011 inhibits the growth of SW620 and HCT116 colorectal cancer cells (IC50s = 0.14 and 0.91 µM, respectively) and enhances cell death induced by DNA topoisomerase I inhibitor irinotecan in the same cells when used at concentrations of 10, 30, and 100 nM. It also increases irradiation-induced cell death in SW620 cells. In vivo, A011 (5 mg/kg) increases irinotecan-induced reductions in tumor growth in an SW620 mouse xenograft model.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *