ACY-957 |
| رقم الكتالوجGC30526 |
ACY-957 هو مثبط نشط وانتقائي عن طريق الفم لـ HDAC1 و HDAC2 ، مع IC50s من 7 نانومتر ، 18 نانومتر ، و 1300 نانومتر ضد HDAC1 / 2/3 ، على التوالي ، ولا يظهر أي تثبيط على HDAC4 / 5/6/7/8 / 9
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1609389-52-7
Sample solution is provided at 25 µL, 10mM.
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ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9.
ACY-957 is a selective inhibitor of HDAC1 and HDAC2, with IC50s of 7 nM, 18 nM, and 1300 nM against HDAC1/2/3, respectively, and shows no inhibition on HDAC4/5/6/7/8/9. ACY-957 has an IC50 of 304 nM for HDAC2 in primary hematopoietic progenitors[1].
[1]. Shearstone JR, et al. Chemical Inhibition of Histone Deacetylases 1 and 2 Induces Fetal Hemoglobin through Activation of GATA2. PLoS One. 2016 Apr 13;11(4):e0153767.
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