Adefovir (Synonyms: GS-0393, PMEA) |
| رقم الكتالوجGC42731 |
Adefovir (GS-0393) هو عامل مضاد للفيروسات تناظري أدينوزين أحادي الفوسفات والذي بعد التحويل داخل الخلايا إلى Adefovir diphosphate يثبط HBV DNA polymerase
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Cas No.: 106941-25-7
Sample solution is provided at 25 µL, 10mM.
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Adefovir is an acyclic nucleoside phosphonate that acts as a reverse transcriptase inhibitor. When evaluated in animal and clinical models of infections, its antiviral spectrum was shown to uniquely encompass activity against herpes viruses (HSV-1, HSV-2, VZV, CMV, EBV, HHV-6, HHV-7, and HHV-8), hepatitis B virus (HBV), and HIV (HIV-1, HIV-2, SIV, and FIV). Adefovir-associated resistance mutations have not yet been observed in HBV resistance surveillance clinical studies.
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