Alafosfalin |
| رقم الكتالوجGC70486 |
Alafosfalin هو مثبط للجدار الخلوي الحيوي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60668-24-8
Sample solution is provided at 25 µL, 10mM.
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Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter[1].
After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t1/2) of approximately 20 minutes[2].
References:
[1]. H B Maruyama, et al. Alafosfalin, a New Inhibitor of Cell Wall Biosynthesis: In Vitro Activity Against Urinary Isolates in Japan and Potentiation With Beta-Lactams. Antimicrob Agents Chemother. 1979 Oct;16(4):444-51.
[2]. J G Allen, et al. Phosphonopeptides as Antibacterial Agents: Metabolism and Pharmacokinetics of Alafosfalin in Animals and Humans. Antimicrob Agents Chemother. 1979 Sep;16(3):306-13.
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