Amino-PEG10-OH |
| رقم الكتالوجGC67176 |
Amino-PEG10-OH عبارة عن رابط PEG ADC مكون من 10 وحدات غير قابل للكسر يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs). Amino-PEG10-OH هو أيضًا رابط PROTAC قائم على PEG ويمكن استخدامه في تركيب PROTACs.
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Cas No.: 129449-09-8
Sample solution is provided at 25 µL, 10mM.
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Amino-PEG10-OH is non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Amino-PEG10-OH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. James Bailey, et al. Non peptidic heterobivalent molecules for treating inflammatory diseases. WO2018134731A1.
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