Amyloid-β (1-40) Peptide (human) (trifluoroacetate salt) (Synonyms: Aβ (1-40), Aβ40) |
رقم الكتالوجGC46850 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
Amyloid-β (1-40) (Aβ40) peptide is a 40-residue protein fragment of Aβ42 , a neurotoxic peptide found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease.1,2 Aβ40 is more abundant, less neurotoxic, and does not form oligomers as easily as Aβ42.3,4 Aβ40 inhibits in vitro fibrillization of Aβ42 in a concentration-dependent manner.5 It also inhibits Aβ42-induced cell death in cultured rat embryonic cortical neurons in a concentration-dependent manner. Aβ40 prevents Aβ42-induced increases in the number of GFAP-positive astrocytes in rat entorhinal cortex.
1.Wolfe, M.S.Therapeutic strategies for Alzheimer's diseaseNat. Rev. Drug Discov.1(11)859-866(2002) 2.Iwatsubo, T., Odaka, A., Suzuki, N., et al.Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)Neuron13(1)45-53(1994) 3.Bitan, G., Kirkitadze, M.D., Lomakin, A., et al.Amyloid β-protein (Aβ) assembly: Aβ40 and Aβ42 oligomerize through distinct pathwaysProc. Natl. Acad. Sci. USA100(1)330-335(2003) 4.Murphy, M.P., and LeVinne, H., IIIAlzheimer's disease and the β-amyloid peptideJ. Alzheim. Dis.19(1)311(2010) 5.Zou, K., Kim, D., Kakio, A., et al.Amyloid β-protein (Aβ)1-40 protects neurons from damage induced by Aβ1-42 in culture and in rat brainJ. Neurochem.87(3)609-619(2003)
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