Angiopep-2 hydrochloride |
| رقم الكتالوجGC61479 |
Angiopep-2 هيدروكلوريد هو ناقل ببتيد في المخيمكن أن يؤدي اقتران العوامل المضادة للسرطان مع ناقل الببتيد Angiopep-2 إلى زيادة فعاليتها في علاج سرطان الدماغ
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer[1].
Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel- Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar to that of paclitaxel against human cancer cell lines[1].
ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells[1].
[1]. A RÉgina, et al. Antitumour Activity of ANG1005, a Conjugate Between Paclitaxel and the New Brain Delivery Vector Angiopep-2. Br J Pharmacol. 2008 Sep;155(2):185-97.
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