AP C5 |
| رقم الكتالوجGC50527 |
يعرض AP C5 تثبيطًا انتقائيًا لـ guanosine 3 ، 5′-cyclic monophosphate (cGMP) - بروتين كيناز II المعتمد (cGKII) مع pIC50 من 7.2 ، والذي يمكن استخدامه للبحث في أمراض الإسهال.
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Cas No.: 2234272-10-5
Sample solution is provided at 25 µL, 10mM.
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Potent and selective protein kinase G type II (PKG2) inhibitor (pIC50 = 7.2). Displays >20-fold selectivity for PKG2 over PKG1 and PKA (pIC50 values are 4.6 and 4.8 for PKG1 and PKA, respectively). Blocks 8-pCPT-cGMP-dependent VASP phosphorylation in intestinal organoids. Also attenuates toxin-stimulated anion secretory responses in mouse intestinal tissue.
Bijvelds et al (2018) Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J.Biol.Chem. 293 8173 PMID:29653944
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)
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