الصفحة الرئيسية>>Signaling Pathways>> Metabolism>> Factor Xa>>ARC19499 sodium

ARC19499 sodium

رقم الكتالوجGC71242

ARC19499 sodium هو أبتمر يمنع مثبط مسار عامل الأنسجة (TFPI)، وبالتالي تمكين بدء الجلطة والانتشار عبر المسار الخارجي.

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ARC19499 sodium التركيب الكيميائي

الحجم السعر المخزون الكميّة
1 mg
297٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
ARC19499 sodium is an aptamer that inhibits tissue factor pathway inhibitor (TFPI) , thereby enabling clot initiation and propagation via the extrinsic pathway. The core aptamer binds tightly and specifically to TFPI. ARC19499 sodium blocks TFPI inhibition of both factor Xa and the TF/factor VIIa complex. ARC19499 sodium corrects thrombin generation in hemophilia A and B plasma and restores clotting in FVIII-neutralized whole blood.

References:
[1]. Waters EK, Genga RM, Schwartz MC, et al. Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor.Blood. 2011;117(20):5514-5522.
[2]. Gissel M, Orfeo T, Foley JH, Butenas S. Effect of BAX499 aptamer on tissue factor pathway inhibitor function and thrombin generation in models of hemophilia.Thromb Res. 2012;130(6):948-955.

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