ARN 077 (URB913) (Synonyms: URB913) |
رقم الكتالوجGC31913 |
ARN 077 (URB913) هو مثبط قوي وانتقائي لحمض N-acylethanolamine amidase (NAAA) مع IC50 من 7 نانومتر للإنسان NAAA.
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Cas No.: 1373625-34-3
Sample solution is provided at 25 µL, 10mM.
ARN 077 is a potent and selective N-acylethanolamine acid amidase (NAAA) inhibitor with an IC50 of 7 nM for human NAAA[1]. ARN 077 significantly increases palmitoyl ethanolamine (PEA) levels within the CNS and has broad antinociceptive activity in mice and rats[2].
[1]. Sasso O, et al. Antinociceptive effects of the N-acylethanolamine acid amidase inhibitor ARN077 in rodent pain models. Pain. 2013 Mar;154(3):350-60. [2]. Davis MP, et al. Cannabinoids in pain management: CB1, CB2 and non-classic receptor ligands. Expert Opin Investig Drugs. 2014 Aug;23(8):1123-40.
Average Rating: 5
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