Asfotase alfa |
| رقم الكتالوجGC70297 |
Asfotase alfa (ENB-0040) هو بروتين سكري موجه وراثيا للعظام.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1174277-80-5
Sample solution is provided at 25 µL, 10mM.
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Asfotase alfa (ENB-0040) is a bone-targeted genetically engineered glycoprotein. Asfotase alfa increases the survival rate, bone mineralization and bone length and prevents mineralization defects of the feet, rib cage, lower limbs, jaw bones in Akp2−/− knockout mice. Asfotase alfa can be used for the research of perinatal, infantile, and juvenile-onset hypophosphatasia (HPP).
Asfotase alfa (0.5-8.2 mg/kg; s.c. once daily for 43 days) shows dose-response relationships that strongly support the pharmacological efficacy for HPP[1].
References:
[1]. Yadav MC, et al. Dose response of bone-targeted enzyme replacement for murine hypophosphatasia. Bone. 2011 Aug;49(2):250-6.
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Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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