Avrainvillamide (Synonyms: CJ-17,665) |
رقم الكتالوجGC48511 |
أفراينفيلاميد ((+) - أفراينفيلاميد) عبارة عن قلويد طبيعي له تأثيرات مضادة للتكاثر ، ويرتبط بالنيوكليوفوسمين الموصوف النووي ، وهو بروتين مقترح للورم يتم التعبير عنه بشكل مفرط في العديد من الأورام البشرية المختلفة
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Cas No.: 269741-97-1
Sample solution is provided at 25 µL, 10mM.
Avrainvillamide is a fungal metabolite and monomeric form of stephacidin B that has been found in A. ochraceus.1,2 It is active against S. aureus, S. pyogenes, and E. faecalis (MICs = 12.5, 12.5, and 25 µg/ml, respectively).2 Avrainvillamide inhibits the growth of LNCaP, BT-549, T47D, and MALME-3M cancer cells with GI50 values of 0.24, 0.62, 0.21, and 0.41 µM, respectively.1
1.Wulff, J.E., Herzon, S.B., Siegrist, R., et al.Evidence for the rapid conversion of stephacidin B into the electrophilic monomer avrainvillamide in cell cultureJ. Am. Chem. Soc.129(16)4898-4899(2007) 2.Sugie, Y., Hirai, H., Inagaki, T., et al.A new antibiotic CJ-17,665 from Aspergillus ochraceusJ. Antibiot.54(11)911-916(2001)
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