AWL-II-38.3 |
| رقم الكتالوجGC63301 |
AWL-II-38.3 هو مثبط قوي لمستقبلات الإيفرين أ (EphA3) كينازلا يُظهر AWL-II-38.3 نشاطًا خلويًا كبيرًا ضد إنزيمات عائلة Src ولا ضد b-raf
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Cas No.: 1135205-94-5
Sample solution is provided at 25 µL, 10mM.
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AWL-II-38.3 is a potent ephrin-A receptor (EphA3) kinase inhibitor. AWL-II-38.3 does not exhibit significant cellular activity against Src-family kinases nor against b-raf[1][2][1][2].
AWL-II-38.3 fits to LIMK2 and LIMK1 ATP-binding and substrate-binding pockets[2].
[1]. Yongmun Choi, et al. Discovery and structural analysis of Eph receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4467-70.
[2]. Efrat Mashiach-Farkash, et al. Computer-based identification of a novel LIMK1/2 inhibitor that synergizes with salirasib to destabilize the actin cytoskeleton. Oncotarget. 2012 Jun;3(6):629-39.
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