Azaguanine-8 |
| رقم الكتالوجGC11843 |
Azaguanine-8 هو نظير البيورين الذي يظهر نشاط مضاد الأورام. يعمل Azaguanine-8 كمضاد للأيض ويمكن دمجه بسهولة في الأحماض النووية الريبية ، مما يتداخل مع مسارات التخليق الحيوي الطبيعية ، وبالتالي يمنع النمو الخلوي.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 134-58-7
Sample solution is provided at 25 µL, 10mM.
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8-Azaguanine is a purine analogue which shows antineoplastic activity.
8-Azaguanine is a purine analogue which shows antineoplastic activity. The results show that cell viability decreases after incubation with 8-Azaguanine, in a dose and time dependent manner. After 24 h of treatment with 8-Azaguanine the IC50 for CEM cell line is about 100 μM while for MOLT3 cell line the IC50 is about 10 μM. CEM and MOLT3 cells surface expression of CD26 increases after treatment with 8-Azaguanine in a concentrations dependent manner[1].
References:
[1]. Dourado M, et al. CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture. Pathophysiology. 2007 May;14(1):3-10.
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