Azido-PEG2-C2-amine |
| رقم الكتالوجGC60067 |
Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) عبارة عن رابط PROTAC قائم على PEG يمكن استخدامه في تركيب PROTACsAzido-PEG2-C2-amine هو أيضًا رابط PEG ADC مكون من وحدتين غير قابل للانشقاق يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)
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Cas No.: 166388-57-4
Sample solution is provided at 25 µL, 10mM.
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Azido-PEG2-C2-amine (N3-PEG2-CH2CH2NH2) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG2-C2-amine is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582. [2]. Tominari, Yusuk , et al. Heterocyclic compound. WO2020027225A1.
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