Benzcyclane (Bencyclane) |
| رقم الكتالوجGC32506 |
Benzcyclane (Bencyclane) (Bencyclane ؛ Benzcyclan) هو مثبط لتجمع الصفائح الدموية وموسع للأوعية فعال في مجموعة متنوعة من اضطرابات الدورة الدموية الطرفية.
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Cas No.: 2179-37-5
Sample solution is provided at 25 µL, 10mM.
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Benzcyclane (Bencyclane; Benzcyclan) is a platelet aggregation inhibitor and a vasodilator effective in a variety of peripheral circulation disorders.
Benzcyclane, although capable of aggregating platelets by itself at very high concentrations, shows a striking inhibitory effect, over a wide range of concentrations, both on platelet aggregation induced by ADP, epinephrine or collagen and on platelet adhesiveness to glass or collagen. Clot retraction is also clearly inhibited[1]. Benzcyclane induces use-dependent inhibition of Na channels in muscle, similarly as do class 1 antiarrhytnmic drugs. Inhibition was observed with both normal and cevadine-modified Na channels[2].
[1]. Ponari O, et al. In vitro effects of bencyclan on coagulation, fibrinolysis and platelet function. Arzneimittelforschung. 1976;26(8):1532-8. [2]. Nánási PP, et al. Effects of bencyclane on normal and cevadine-modified Na channels in frog skeletal muscle. Gen Physiol Biophys. 1989 Oct;8(5):447-58.
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