Bis-PEG25-NHS ester |
| رقم الكتالوجGC67452 |
إستر Bis-PEG25-NHS عبارة عن رابط PROTAC قائم على PEG / Alkyl / ether يمكن استخدامه في تخليق PROTACs. إستر Bis-PEG25-NHS عبارة عن رابط ADC قابل للانقسام يستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs).
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Cas No.: 2221948-96-3
Sample solution is provided at 25 µL, 10mM.
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Bis-PEG25-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG25-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
[1]. John L. Magnani, et al. Highly potent multimeric e-selectin antagonists. WO2018068010A1
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