BPN-15477 |
| رقم الكتالوجGC64420 |
BPN-15477 عبارة عن SMC قوي (مركب معدل الربط) الذي يعيد الربط الصحيح لـ ELP1 (بروتين مركب Elongator 1) exon 20
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Cas No.: 1971086-99-3
Sample solution is provided at 25 µL, 10mM.
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BPN-15477 is a potent SMC (splicing modulator compound) that restores correct splicing of ELP1 (Elongator complex protein 1) exon 20. BPN-15477 corrects splicing of the ELP1 transcript, significantly increases the level of functional protein in vivo in all tissues, including brain. BPN-15477 can be used for frontotemporal dementia research[1].
[1]. Gao D, et al. A deep learning approach to identify gene targets of a therapeutic for human splicing disorders. Nat Commun. 2021 Jun 7;12(1):3332.
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