Bragsin2 |
| رقم الكتالوجGC64939 |
براغسين 2 هو مثبط عامل تبادل النوكليوتيدات القوي ، الانتقائي وغير التنافسي BRAG2 ، مع IC 50 من 3 ميكرومتريرتبط Bragsin2 عند الواجهة بين مجال PH الخاص بـ BRAG2 والطبقة الدهنية الثنائية ، مما يؤدي إلى عدم قدرة BRAG2 على تنشيط Arf GTPase الدهنييؤثر براغسين 2 على الخلايا الجذعية لسرطان الثدي
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Cas No.: 342795-08-8
Sample solution is provided at 25 µL, 10mM.
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Bragsin2 is a potent, selective and noncompetitive nucleotide exchange factor BRAG2 inhibitor, with an IC50 of 3 μM. Bragsin2 binds at the interface between the PH domain of BRAG2 and the lipid bilayer, leads BRAG2 unable to activate lipidated Arf GTPase. Bragsin2 affects breast cancer stem cells[1].
Bragsin2 (50 μM) inhibits Arf GTPase activation in HeLa cells[1].Bragsin2 (50 μM) inhibits the growth of SUM149 and S68, with no effect on SUM159, which lacks adhesion molecules such as integrins and cadherins[1].
[1]. Nawrotek A, et al. PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling. Nat Chem Biol. 2019 Feb 11. doi: 10.1038/s41589-019-0228-3.
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