Bromo-PEG2-C2-azide |
| رقم الكتالوجGC63609 |
Bromo-PEG2-C2-azide عبارة عن رابط ADC غير قابل للكسر يُستخدم في تخليق اتحادات الأجسام المضادة والأدوية (ADCs)Bromo-PEG2-C2-azide هو أيضًا رابط PROTAC قائم على PEG ويمكن استخدامه في تركيب PROTACs
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Cas No.: 530151-56-5
Sample solution is provided at 25 µL, 10mM.
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Bromo-PEG2-C2-azide is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bromo-PEG2-C2-azide is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
[1]. Yong Zu Kim, et al. Antibody-drug conjugates comprising branched linkers and methods related thereto. WO2017089895A1.
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