BSP-16 |
| رقم الكتالوجGC90705 |
محفز STING
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2727249-47-8
Sample solution is provided at 25 µL, 10mM.
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BSP-16 is a stimulator of interferon genes (STING) agonist.1 It binds to STING (Kd = 23 µM) and induces the production of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells when used at concentrations of 10, 25, and 50 µM. BSP-16 (50 µM) induces phosphorylation of IFN regulatory factor 3 (IRF3) and TANK-binding kinase 1 (TBK1) in THP-1 cells. In vivo, BSP-16 (15 and 30 mg/kg) reduces tumor volume in an MC-38 murine carcinoma model and induces tumor regression in a CT26 murine colorectal carcinoma model. It prevents tumor cell re-challenge-induced tumor formation in a CT26 murine carcinoma model. BSP-16 (20 mg/kg) also reduces tumor volume and increases the number of activated CD8+ T cells and natural killer (NK) cells in a 4T1 murine mammary carcinoma model.
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