الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> Glucocorticoid Receptor>>C108297

C108297

رقم الكتالوجGC70575

C108297 هو مُعدل انتقائي لمستقبلات القشرانيات السكرية (GR) (مرتبط Gi 0.7 نانومتر ؛ جين مراسل GR الوظيفي Ki 0.6 نانومتر).

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C108297 التركيب الكيميائي

Cas No.: 864972-30-5

الحجم السعر المخزون الكميّة
1 mg
511٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents
C108297 is a selective glucocorticoid receptor (GR) modulator (GR binding Ki 0.7 nM; GR reporter gene functional Ki 0.6 nM). C108297 attenuates obesity by reducing caloric intake and increasing lipolysis and fat oxidation, and in addition attenuates inflammation.

References:
[1]. Clark RD, et al. 1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity. Bioorg Med Chem Lett. 2008;18(4):1312-1317.
[2]. van den Heuvel JK, et al. Identification of a selective glucocorticoid receptor modulator that prevents both diet-induced obesity and inflammation. Br J Pharmacol. 2016;173(11):1793-1804.

مراجعات

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