C22 Glucosylceramide-d4 (d18:1/22:0-d4) (Synonyms: N-Docosanoyl-glucopsychosine-d4, N-Docosanoyl-β-glucosylsphingosine-d4, GluCer(18:1/22:0-d4), N-C22:0-Glucocerebroside-d4, C22 Glucosylceramide-d4, Glucosylceramide-d4 (d18:1/22:0-d4))

C22 Glucosylceramide-d₄ is intended for use as an internal standard for the quantification of C22 glucosylceramide by GC- or LC-MS. C22 Glucosylceramide is an endogenous glucosylceramide.^1,2,3 Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A₂ (PLA₂) type XIIA knockdown increases C22 glucosylceramide expression in rat brain.³ It is also increased in the brain, but not the liver or spinal cord, of mice fed a methionine-restricted diet.² In human athletes, plasma levels of C22 glucosylceramide increase during exercise and return to basal levels during recovery.¹ [Matreya, LLC.]

1.Bergman, B.C., Brozinick, J.T., Strauss, A., et al.Serum sphingolipids: Relationships to insulin sensitivity and changes with exercise in humansAm. J. Physiol. Endocrinol. Metab.309(4)E398-E408(2015) 2.JovÉ, M., Ayala, V., RamÍrez-NÚÑez, O., et al.Specific lipidome signatures in central nervous system from methionine-restricted miceJ. Proteome Res.12(6)2679-2689(2013) 3.Ee, S.-M., Lo, Y.-L., Shui, G., et al.Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognitionMol. Neurobiol.50(1)60-75(2014)