Carfilzomib-d8 |
| رقم الكتالوجGC47042 |
معيار داخلي لتحديد كمية الكارفيلزوميب
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1537187-53-3
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Carfilzomib-d8 is intended for use as an internal standard for the quantification of carfilzomib by GC- or LC-MS. Carfilzomib is an irreversible proteosome inhibitor classified as a peptide epoxyketone. It targets the chymotrypsin-like β5 subunit of the constitutive 20S proteasome (IC50 = 5.2 nM) and the β5i subunit of the immunoproteasome 20Si (LMP7; IC50 = 14 nM) with minimal cross reactivity to other proteases.1,2 It can induce cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma, lymphoma, and various solid tumors (IC50s = 2.4-20 nM).3,4
1.Dou, Q.P., and Zonder, J.A.Overview of proteasome inhibitor-based anti-cancer therapies: Perspective on bortezomib and second generation proteasome inhibitors versus future generation inhibitors of ubiquitin-proteasome systemCurr. Cancer Drug Targets14(6)517-536(2014) 2.Zhou, H.J., Aujay, M.A., Bennett, M.K., et al.Design and synthesis of an orally bioavailable and selective peptide epoxyketone proteasome inhibitor (PR-047)J. Med. Chem.52(9)3028-3038(2009) 3.Zhang, W., and Sidhu, S.S.Development of inhibitors in the ubiquitination cascadeFEBS Lett.588(2)356-367(2014) 4.Demo, S.D., Kirk, C.J., Aujay, M.A., et al.Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasomeCancer Res.67(13)6383-6391(2007)
| Cas No. | 1537187-53-3 | SDF | |
| Canonical SMILES | O=C([C@]1(C)OC1)[C@H](CC(C)C)NC([C@@H](NC([C@@H](NC([C@H](CCC2=CC=CC=C2)NC(CN3C([2H])([2H])C([2H])([2H])OC([2H])([2H])C3([2H])[2H])=O)=O)CC(C)C)=O)CC4=CC=CC=C4)=O | ||
| Formula | C40H49D8N5O7 | M.Wt | 728 |
| الذوبان | DMF: 15 mg/ml,DMSO: 15 mg/ml,Ethanol: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.3736 mL | 6.8681 mL | 13.7363 mL |
| 5 mM | 0.2747 mL | 1.3736 mL | 2.7473 mL |
| 10 mM | 0.1374 mL | 0.6868 mL | 1.3736 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 9 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *