CAY10621 (Synonyms: SKI 5C, SPHK1 Inhibitor 5C) |
| رقم الكتالوجGC43183 |
CAY10621 (SKI 5C ؛ المركب 5 ج) هو مثبط محدد للسينغوزين كيناز 1 (SPHK1) مع IC 50 من 3.3 ميكرومترCAY10621 منخفض السمية تجاه الخلايالدى CAY10621 القدرة على إجراء أبحاث عن أورام السرطان المقاومة
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 120005-55-2
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
CAY10621 is an inhibitor of sphingosine kinase 1 (SPHK1; IC50 = 3.3 μM).[1] It is selective for SPHK1 over SPHK2 at 10 μM and PKC at concentrations less than 100 μM. CAY10621 inhibits SPHK1 activity by 70% in U937 cells when used at a concentration of 5 μM.
Reference:
1. Wong, L., Tan, S.L., Lam, Y., et al. Synthesis and evaluation of sphingosine analogues as inhibitors of sphingosine kinases. Journal of Medicinal Chemistry 52, 3618-3626 (2009).
Average Rating: 5 (Based on Reviews and 1 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *