CB1/2 agonist 3 |
رقم الكتالوجGC71112 |
CB1/2 agonist 3 (مركب 52)، ربيطة الكانابينويد الفعالة غير الانتقائية، هو ناهض تنافسي CB1/CB2 (مستقبلات الكانابينويد).
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Cas No.: 2772655-86-2
Sample solution is provided at 25 µL, 10mM.
CB1/2 agonist 3 (compound 52) can partially induce [35S]GTPγS binding to hCB1-CHO cell membranes with an EC50 value of 30.99 nM, and slightly inhibit [35S]GTPγS binding to hCB2-CHO cell membranes with a mean EC50 value of 1.28 nM[1].
CB1/2 agonist 3 (compound 52) ((1 μM, 1 h) has antagonistic effect on CB1/CB2 agonist CP-55940 with a Kb value of 78.17 nM[1].
References:
[1]. Antonella Brizzi, et al. Synthetic bioactive olivetol-related amides: The influence of the phenolic group in cannabinoid receptor activity. Bioorg Med Chem. 2020 Jun 1;28(11):115513.
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