CCR4 antagonist 4 |
| رقم الكتالوجGC71428 |
CCR4 antagonist 4 (المركب 22) هو مضاد انتقائي وقوي لمستقبل CCR4 (CCR4)، مع IC50 من 0.02 ميكرون.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 668980-17-4
Sample solution is provided at 25 µL, 10mM.
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CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research.
References:
[1]. Purandare AV, et al. Core exploration in optimization of chemokine receptor CCR4 antagonists. Bioorg Med Chem Lett. 2007 Feb 1;17(3):679-82.
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