CCR6 inhibitor 1 |
| رقم الكتالوجGC34521 |
مثبط CCR6 1 هو مثبط CCR6 قوي وانتقائي ، مع IC50s من 0.45 و 6 نانومتر للقرد و CCR6 البشري ، أكثر انتقائية في CCR6 على CCR1 البشري (IC50 ،> 30000 نانومتر) ، و CCR7 (IC50 ، 9400 نانومتر)
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Cas No.: 2437547-04-9
Sample solution is provided at 25 µL, 10mM.
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CCR6 inhibitor 1 is a potent and selective CCR6 inhibitor, with IC50s of 0.45 and 6 nM for monkey and human CCR6, much more selective at CCR6 over human CCR1 (IC50, > 30000 nM), and CCR7 (IC50, 9400 nM). CCR6 inhibitor 1 markedly blocks ERK phosphorylation. CCR6 inhibitor 1 is used in the research of autoimmune diseases and cancer[1]. Moneky CCR6|0.45 nM (IC50)|Human CCR6|6 nM (IC50)|Human CCR7|9400 nM (IC50)
CCR6 inhibitor 1 (Compound 35) inhibits L20-induced human B cell migration[1].
[1]. Tawaraishi T, et al. Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett. 2018 Oct 1;28(18):3067-3072.
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