CD73-IN-3 |
| رقم الكتالوجGC62331 |
CD73-IN-3 هو مثبط قوي لـ CD73 (IC50 = 7.3 نانومتر في اختبار الخلية البشرية Calu6)CD73-IN-3 ، المثال 2 المستخرج من براءة اختراع WO2019168744 A1 ، لديه إمكانات لأبحاث السرطان
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Cas No.: 2375815-63-5
Sample solution is provided at 25 µL, 10mM.
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CD73-IN-3 is a potent CD73 inhibitor (IC50=7.3 nM in Calu6 human cell assay). CD73-IN-3, example 2 extracted from patent WO2019168744 A1, has the potential for cancer research[1].
CD73-IN-3 inhibits CD73 activity in human serum with an EC50 of 0.213 μM. CD73-IN-3 inhibits CD73 activity in human serum by 56.8%, 71.7% and 76.9% at 0.52 μM, 1.56 μM, 4.68 μM,respectively[1].In Calu6 human cell assay against CD73, the IC50 for CD73-IN-3 against CD73 is 0.0073 uM[1].
[1]. Robert Dean Dally, et al. Cd73 inhibitors. Patent WO2019168744 A1.
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